RESUMO
BACKGROUND: Not all patients fulfil criteria for specific autoimmune rheumatic diseases (ARDs) and are then defined as having non-criteria (nc)ARD. It is uncertain whether well-recognised associations with adverse pregnancy outcomes in patients with criteria ARD also exist in patients with ncARD or undifferentiated connective tissue disease (UCTD). Therefore, we undertook a systematic review of the prevalence of adverse pregnancy outcomes in various ncARD and UCTD compared with criteria ARD to identify whether there are increased risks and to examine for any benefits of treatment. METHODS: This study was conducted in accordance with the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. A systematic literature review was performed using online databases including Medline and PubMed from inception to the beginning of April 2021 using appropriate keywords for various ARD and pregnancy outcomes. RESULTS: After screening 665 articles, 36 articles were chosen for full text review and 15 selected for final analysis. There were eight studies of nc antiphospholipid syndrome (APS) of more than 7000 pregnancies and seven studies of UCTD of more than 1000 pregnancies. No studies of any other ncARD in pregnancy were identified. We found that patients with either ncAPS or UCTD seem to have an increased burden of poor pregnancy outcomes compared with the general population. Despite the heterogeneity and poor quality of the studies, we also noted that ncAPS and criteria APS patients may have similar rates of obstetric complications with standard and/or non-standard APS treatment regimens. CONCLUSION: Our findings of increased risks of poor pregnancy outcomes in patients with ncAPS or UCTD will be helpful for pre-pregnancy counselling and management of these patients in pregnancy and support their referral to specialist obstetric-rheumatology and obstetric-haematology clinics.
Assuntos
Síndrome Antifosfolipídica , Doenças Autoimunes , Lúpus Eritematoso Sistêmico , Complicações na Gravidez , Doenças do Tecido Conjuntivo Indiferenciado , Síndrome Antifosfolipídica/diagnóstico , Síndrome Antifosfolipídica/epidemiologia , Doenças Autoimunes/epidemiologia , Feminino , Humanos , Gravidez , Complicações na Gravidez/epidemiologia , Resultado da GravidezRESUMO
No disponible
Assuntos
Humanos , Masculino , Adulto , Intoxicação/diagnóstico por imagem , Intoxicação/terapia , Acetonitrilas/toxicidade , Acetonitrilas/efeitos adversos , Exposição Ocupacional/efeitos adversos , Astenia/complicações , Anorexia/complicações , Leucocitose/diagnóstico , Gasometria , Oxigênio/uso terapêuticoRESUMO
No disponible
Assuntos
Humanos , Masculino , Idoso de 80 Anos ou mais , Miastenia Gravis/complicações , Leucemia Linfocítica Crônica de Células B/complicações , Miastenia Gravis/tratamento farmacológico , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Radiografia Torácica , Autoimunidade , Biópsia , Medula Óssea/cirurgia , Imunoglobulinas/administração & dosagem , Ciclofosfamida/administração & dosagemRESUMO
A case of spue-like enteropathy due to olmesartan is reported to draw attention to this disease, given the high frequency of use of this drug and the difficulty of diagnosis if the entity if it is not known. In his journal one case was published as Clinical Note in 2014 and we wish to emphasize the importance of knowledge about this relatively new entity.
Assuntos
Bloqueadores do Receptor Tipo 1 de Angiotensina II/efeitos adversos , Doença Celíaca/induzido quimicamente , Imidazóis/efeitos adversos , Enteropatias/induzido quimicamente , Tetrazóis/efeitos adversos , Idoso , Diarreia , Humanos , MasculinoRESUMO
No disponible
